Wondering about the best against-the-spread bet among all 16 NFL matchups in Week 4? Our selection, in terms of ATS, is Raiders -1. But scroll down, because we have plenty more tips, and that could lead to parlay possibilities.

NFL Picks Against the Spread – Week 4

Jump to Matchup:

Pick: Raiders -1 vs. Browns

• Matchup: Cleveland Browns at Las Vegas Raiders
• Projected Winner & Margin: Raiders by 6.3 points (Bet on this game at BetMGM)
• Spread: Raiders -1
• Time: 4:25 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Saints +1.5 vs. Falcons

• Matchup: New Orleans Saints at Atlanta Falcons
• Projected Winner & Margin: Saints by 0.4 points (Bet on this game at BetMGM)
• Spread: Falcons -1.5
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Dolphins +1.5 vs. Titans

• Matchup: Tennessee Titans at Miami Dolphins
• Projected Winner & Margin: Dolphins by 5.0 points (Bet on this game at BetMGM)
• Spread: Titans -1.5
• Time: 7:30 PM ET
• Date: Sept. 30
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Steelers -2 vs. Colts

• Matchup: Pittsburgh Steelers at Indianapolis Colts
• Projected Winner & Margin: Steelers by 4.5 points (Bet on this game at BetMGM)
• Spread: Steelers -2
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Buccaneers +2.5 vs. Eagles

• Matchup: Philadelphia Eagles at Tampa Bay Buccaneers
• Projected Winner & Margin: Buccaneers by 2.5 points (Bet on this game at BetMGM)
• Spread: Eagles -2.5
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Vikings +2.5 vs. Packers

• Matchup: Minnesota Vikings at Green Bay Packers
• Projected Winner & Margin: Packers by 1.2 points (Bet on this game at BetMGM)
• Spread: Packers -2.5
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bills +2.5 vs. Ravens

• Matchup: Buffalo Bills at Baltimore Ravens
• Projected Winner & Margin: Ravens by 1.0 points (Bet on this game at BetMGM)
• Spread: Ravens -2.5
• Time: 8:20 PM ET
• Date: Sept. 29
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Rams +3 vs. Bears

• Matchup: Los Angeles Rams at Chicago Bears
• Projected Winner & Margin: Rams by 1.1 points (Bet on this game at BetMGM)
• Spread: Bears -3
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Cardinals -3.5 vs. Commanders

• Matchup: Washington Commanders at Arizona Cardinals
• Projected Winner & Margin: Cardinals by 7.3 points (Bet on this game at BetMGM)
• Spread: Cardinals -3.5
• Time: 4:05 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Seahawks +3.5 vs. Lions

• Matchup: Seattle Seahawks at Detroit Lions
• Projected Winner & Margin: Lions by 2.9 points (Bet on this game at BetMGM)
• Spread: Lions -3.5
• Time: 8:15 PM ET
• Date: Sept. 30
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Panthers +4.5 vs. Bengals

• Matchup: Cincinnati Bengals at Carolina Panthers
• Projected Winner & Margin: Panthers by 0.9 points (Bet on this game at BetMGM)
• Spread: Bengals -4.5
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Giants +5.5 vs. Cowboys

• Matchup: Dallas Cowboys at New York Giants
• Projected Winner & Margin: Cowboys by 1.1 points (Bet on this game at BetMGM)
• Spread: Cowboys -5.5
• Time: 8:15 PM ET
• Date: Sept. 26
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Texans -7 vs. Jaguars

• Matchup: Jacksonville Jaguars at Houston Texans
• Projected Winner & Margin: Texans by 8.5 points (Bet on this game at BetMGM)
• Spread: Texans -7
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Broncos +7.5 vs. Jets

• Matchup: Denver Broncos at New York Jets
• Projected Winner & Margin: Broncos by 1.3 points (Bet on this game at BetMGM)
• Spread: Jets -7.5
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Chargers +8 vs. Chiefs

• Matchup: Kansas City Chiefs at Los Angeles Chargers
• Projected Winner & Margin: Chargers by 2.4 points (Bet on this game at BetMGM)
• Spread: Chiefs -8
• Time: 4:25 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: 49ers -10 vs. Patriots

• Matchup: New England Patriots at San Francisco 49ers
• Projected Winner & Margin: 49ers by 10.6 points (Bet on this game at BetMGM)
• Spread: 49ers -10
• Time: 4:05 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Catch every NFL touchdown with NFL RedZone on Fubo.

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.